抗ヒト Klotho モノクローナル抗体 (Clone No.KM2076)


容量	50μg/200μL
価格(税別)	お問い合わせください
Data Sheet

免疫抗原：	ヒトKlotho 55-261a.a.
GenBank ID：	9365
免疫動物：	rat（ラット）
精製方法：	ProteinG
抗体サブクラス：	IgG2a

適用	(1.0-5.0μg/mL) (2.0-10μg/mL)
交差性
その他	May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues atpositions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium andphosphorus homeostasis by inhibiting the synthesis of active vitamin D By similarity. Essential factor for the specific interactionbetween FGF23 and FGFR1 By similarity. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which wouldextend life span by inhibiting insulin/IGF1 signaling By similarity.
文献	Biochem Biophys Res Commun. 2000 Jan 19;267(2):597-602. Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. Kato Y, Arakawa E, Kinoshita S, Shirai A, Furuya A, Yamano K, Nakamura K, Iida A, Anazawa H, Koh N, Iwano A, Imura A, Fujimori T, Kuro-o M, Hanai N, Takeshige K, Nabeshima Y. FEBS Lett. 2004 May 7;565(1-3):143-7. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, Fujimori T, Nabeshima Y. Science. 2007 Jun 15;316(5831):1615-8. alpha-Klotho as a regulator of calcium homeostasis. Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, Obuse C, Togashi K, Tominaga M, Kita N, Tomiyama K, Iijima J, Nabeshima Y, Fujioka M, Asato R, Tanaka S, Kojima K, Ito J, Nozaki K, Hashimoto N, Ito T, Nishio T, Uchiyama T, Fujimori T, Nabeshima Y. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3455-60. Epub 2008 Feb 28. A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism. Brownstein CA, Adler F, Nelson-Williams C, Iijima J, Li P, Imura A, Nabeshima Y, Reyes-Mugica M, Carpenter TO, Lifton RP.
共同研究	—