製品リスト

製品名抗 ヒト GRHPR モノクローナル抗体 (Clone No.7G1)

カタログ番号:
KC595
KC595

容量 50μg/200μL
価格(税別) お問い合わせください
Data Sheet Data Sheet
免疫抗原: 部分ペプチド
GenBank ID: 9380
免疫動物: GANP® mouse(GANP®マウス)
精製方法: ProteinG
抗体サブクラス: IgG2b,κ
適用 ELISA(1.0μg/mL) Western Blotting(10-20μg/mL)
交差性 ヒト
その他 //Function Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
//Catalytic activity Glycolate + NADP+ = glyoxylate + NADPH.
D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.
//Subunit structure Homodimer.
//Tissue specificity Ubiquitous. Most abundantly expressed in the liver.
//Involvement in disease Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.
//Sequence similarities Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
文献
共同研究

2010.04.14 発売開始

アイコン説明 アイコン説明

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