抗ヒト GRHPR モノクローナル抗体 (Clone No.7G1)

適用	(1.0μg/mL) (10-20μg/mL)
交差性
その他	//Function Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. //Catalytic activity Glycolate + NADP+ = glyoxylate + NADPH. D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H. //Subunit structure Homodimer. //Tissue specificity Ubiquitous. Most abundantly expressed in the liver. //Involvement in disease Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate. //Sequence similarities Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
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