|//Function: Essential ion channel and serine/threonine-proteinkinase. Divalent cation channel permeableto calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
//Tissue specificity: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver and spleen.
//Sequence similarities: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. In the N-terminal section; belongs to the transient receptor family. LTrpC subfamily. Contains 1 alpha-type protein kinase domain.
|京都大学 森 泰生先生