抗マウス Trpm7 ポリクローナル抗体

適用	(1.0μg/mL)
交差性
その他	//Function: Essential ion channel and serine/threonine-proteinkinase. Divalent cation channel permeableto calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). //Tissue specificity: Found to be expressed in brain and skeletal muscle, with stronger signals in kidney, heart, liver and spleen. //Sequence similarities: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. In the N-terminal section; belongs to the transient receptor family. LTrpC subfamily. Contains 1 alpha-type protein kinase domain.
文献	Am J Physiol Cell Physiol. 2007 Jan;292(1):C460-7. TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells. Numata T, Shimizu T, Okada Y. J Pharmacol Sci. 2004 Aug;95(4):403-19. Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. Hanano T, Hara Y, Shi J, Morita H, Umebayashi C, Mori E, Sumimoto H, Ito Y, Mori Y, Inoue R.
共同研究	京都大学森泰生先生