抗マウス Trpm2 ポリクローナル抗体


容量	25μg/100μL
価格(税別)	お問い合わせください
Data Sheet

免疫抗原：	部分ペプチド
GenBank ID：	28240
免疫動物：	rabbit（ウサギ）
精製方法：	Antigen Affinity
抗体サブクラス：	–

適用	(1.0μg/mL) (1.0-5.0μg/mL) (1.0-5.0μg/mL) (5.0-10μg/mL)
交差性
その他	//Function: Nonselective, voltage-independentcation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellularcalcium passes through the channel and acts from the intracellularside as a positive regulator in channel activation.Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity. //Tissue specificity: Widely expressed, with highest levels in lung, spleen, eye and brain. //Sequence similarities: Belongs to the transient receptor family. LTrpC subfamily. Contains 1 nudix hydrolase domain.
文献	Mol Cell. 2002 Jan;9(1):163-73. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y. EMBO J. 2006 May 3;25(9):1804-15. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M. Nat Med. 2008 Jul;14(7):738-47. TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y.
共同研究	京都大学森泰生先生