抗マウス Trpm2 ポリクローナル抗体

適用	(1.0μg/mL) (1.0-5.0μg/mL)
交差性
その他	//Function: Nonselective, voltage-independentcation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellularcalcium passes through the channel and acts from the intracellularside as a positive regulator in channel activation.Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity. //Tissue specificity: Widely expressed, with highest levels in lung, spleen, eye and brain. //Sequence similarities: Belongs to the transient receptor family. LTrpC subfamily. Contains 1 nudix hydrolase domain.
文献	J Pharmacol Sci. 2006 May;101(1):66-76. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. Kaneko S, Kawakami S, Hara Y, Wakamori M, Itoh E, Minami T, Takada Y, Kume T, Katsuki H, Mori Y, Akaike A.
共同研究	京都大学森泰生先生