|//Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphatereceptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
//Tissue specificity: Abundantly expressed in brain. Concentrated in cerebellar Purkinje cells and sparsely localized in cerebellar granule lyer, pontine nuclei and thalamus. Lower levels detected in other tissues.
//Sequence similarities: Belongs to the transient receptor family. STrpC subfamily. Contains 5 ANK repeats.
|京都大学 森 泰生先生