抗 ラット体性幹細胞認識モノクローナル抗体 (Clone No.A3)

A3 モノクローナル抗体は、悪性線維性組織球腫（MFH:malignant fibrous histocytoma）の組織発生を追及するために、ラットMFH由来クローン細胞株（MT-8）に対して作製された抗体です。
免疫組織化学的な検討の結果、本抗体の抗原はMT-8 の細胞膜上に存在し、分子量はおよそ80kDa であることが確認されています。
本抗体は、これまでの研究結果からラット骨髄の幹細胞を認識することが示されています。その他ラットの肺線維化および肝線維化において未分化間葉系幹細胞も認識することが報告されております。

• • Jpn J Cancer Res. 1991 Mar;82(3):298-307.
    Heterogeneity of cloned cell lines established from a transplantable rat malignant fibrous histiocytoma.
    Yamate J, Tajima M, Togo M, Shibuya K, Ihara M, Kudow S.

• • J Comp Pathol. 2000 Aug-Oct;123(2-3):77-87.
    Distribution of cells labelled by a monoclonal antibody (A3) against a cloned cell line derived from a rat malignant fibrous histiocytoma.
    Kumagai D, Yamate J, Tajima T, Tsukamoto Y, Yasui H, Kuwamura M, Kotani T, Sakuma S.

• • Eur J Cancer. 2007 Dec;43(18):2747-56.
    Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells.
    Yamate J, Ogata K, Yuasa T, Kuwamura M, Takenaka S, Kumagai D, Itoh K, LaMarre J.

• • Histol Histopathol. 2012 Apr;27(4):515-27.
    Immunophenotypical analyses of myofibroblasts in rat excisional wound healing: possible transdifferentiation of blood vessel pericytes and perifollicular dermal sheath cells into myofibroblasts.
    Juniantito V, Izawa T, Yuasa T, Ichikawa C, Yamamoto E, Kuwamura M, Yamate J.

• • Exp Toxicol Pathol. 2013 Nov;65(7-8):1159-71.
    Characterization of glial fibrillary acidic protein (GFAP)-expressing hepatic stellate cells and myofibroblasts in thioacetamide (TAA)-induced rat liver injury.
    Tennakoon AH, Izawa T, Wijesundera KK, Golbar HM, Tanaka M, Ichikawa C, Kuwamura M, Yamate J.

• • Histol Histopathol. 2013 Feb;28(2):257-68.
    Rat hair follicle-constituting cells labeled by a newly-developed somatic stem cell-recognizing antibody: a possible marker of hair follicle development.
    Ichikawa C, Izawa T, Juniantito V, Tanaka M, Hori M, Tanaka K, Takenaka S, Kuwamura M, Yamate J.

• • J Comp Pathol. 2013 May;148(4):385-95.
    Distribution of cells labelled by a novel somatic stem cell-recognizing antibody (A3) in pulmonary genesis and bleomycin induced pulmonary fibrosis in rats.
    Hori M, Juniantito V, Izawa T, Ichikawa C, Tanaka M, Tanaka K, Takenaka S, Kuwamura M, Yamate J.

• • Exp Toxicol Pathol. 2015 Jan;67(1):53-63.
    Immunohistochemical characterization of glial fibrillary acidic protein (GFAP)-expressing cells in a rat liver cirrhosis model induced by repeated injections of thioacetamide (TAA).
    Tennakoon AH, Izawa T, Wijesundera KK, Murakami H, Katou-Ichikawa C, Tanaka M, Golbar HM, Kuwamura M, Yamate J.