抗マウス Fcα/μR モノクローナル抗体 (Clone No.TX61)


容量	50μg/200μL
価格(税別)	お問い合わせください
Data Sheet

免疫抗原：	発現細胞
GenBank ID：	64435
免疫動物：	Fcα/μR K.O. mouse（マウス）
精製方法：	ProteinG
抗体サブクラス：	IgG1,κ

適用	(5.0-10μg/mL) (5.0-10μg/mL) (0.5-1.0μg/mL)
交差性
その他	//Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. //Subcellular location: Cell membrane; Single-pass type I membrane protein. //Tissue specificity: Expressed in several tissues including thymus, spleen, liver, kidney, small and large intestine, testis and placenta. Expressed by oligodendrocytes, B cells and macrophages but not granulocytes, T cells or NK cells (at protein level). //Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
文献	Biochem Biophys Res Commun. 2006 Jun 23;345(1):474-8. Molecular characteristics of IgA and IgM Fc binding to the Fcalpha/muR. Cho Y, Usui K, Honda S, Tahara-Hanaoka S, Shibuya K, Shibuya A. Springer Semin Immunopathol. 2006 Dec;28(4):377-82. Epub 2006 Oct 24. Molecular and functional characteristics of the Fcalpha/muR, a novel Fc receptor for IgM and IgA. Shibuya A, Honda S Mol Immunol. 2009 Feb;46(4):749-53. Epub 2008 Nov 21. Identification of the Fcalpha/muR isoform specifically expressed in the kidney tubules. Kurita N, Honda S, Usui K, Shimizu Y, Miyamoto A, Tahara-Hanaoka S, Shibuya K, Shibuya A. Mol Immunol. 2010 Jan;47(4):878-82. Epub 2009 Nov 27. Requirement of the cytoplasmic portion for dimer formation of Fcα/μ receptor expressed on cell surface Cho Y, Honda S, Yoshizawa Y, Takagaki K, Usui K, Shibuya A.
共同研究	筑波大学渋谷彰先生