ラット抗マウス AIM モノクローナル抗体 #36 (Clone No.23B12)


容量	50μg/200μL
価格(税別)	お問い合わせください
Data Sheet

免疫抗原：	マウス AIM
GenBank ID：	11801
免疫動物：	rat（ラット）
精製方法：	ProteinG
抗体サブクラス：	IgG2a

適用	(1.0μg/mL) (1.0μg/mL) (5μg/mL) (10μg/mL) (10μg/mL)
交差性
その他	//Function: May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis. //Subcellular location:Secreted. //Tissue specificity: Expressed in thymus, liver, spleen and lymph nodes. //Post-translational modification: Glycosylated. //Sequence similarities: Contains 3 SRCR domains.
文献	Cell Reports, 04 April 2013 Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells Satoko Arai, Natsumi Maehara, Yoshihiro Iwamura, Shin-ichiro Honda, Katsuhiko Nakashima, Toshihiro Kai, Masato Ogishi, Kumiko Morita, Jun Kurokawa, Mayumi Mori, Yuji Motoi, Kensuke Miyake, Nobuyuki Matsuhashi, Ken-ichi Yamamura, Osamu Ohara, Akira Shibuya, Edward K. Wakeland, Quan-Zhen Li, Toru Miyazaki Seikagaku. 2012 Jul;84(7):588-91. An optimum method for generation of functional recombinant apoptosis inhibitor of macrophage (AIM) protein Ohba M, Nakashima K, Miyazaki T. Circ J. 2011;75(11):2522-31. Epub 2011 Oct 5. AIMing at metabolic syndrome. -Towards the development of novel therapies for metabolic diseases via apoptosis inhibitor of macrophage (AIM).-. Miyazaki T, Kurokawa J, Arai S. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12072-7. doi: 10.1073/pnas.1101841108. Epub 2011 Jul 5. Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue. Kurokawa J, Nagano H, Ohara O, Kubota N, Kadowaki T, Arai S, Miyazaki T. Cell Metab. 2010 Jun 9;11(6):479-92. doi: 10.1016/j.cmet.2010.04.013. Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity. Kurokawa J, Arai S, Nakashima K, Nagano H, Nishijima A, Miyata K, Ose R, Mori M, Kubota N, Kadowaki T, Oike Y, Koga H, Febbraio M, Iwanaga T, Miyazaki T. Cell Metab. 2005 Mar;1(3):201-13. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. J Exp Med. 1999 January 18; 189(2): 413-422. Increased Susceptibility of Thymocytes to Apoptosis in Mice Lacking AIM, a Novel Murine Macrophage-derived Soluble Factor Belonging to the Scavenger Receptor Cysteine-rich Domain Superfamily Miyazaki T, Hirokami Y, Matsuhashi N, Takatsuka H, Naito M.
共同研究	東京大学宮崎徹先生