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製品名ラット抗 マウス AIM モノクローナル抗体 #29 (Clone No.20C1)

カタログ番号:
KO616
sample

容量 50μg/200μL
価格(税別) ¥57,750
Data Sheet Data Sheet
免疫抗原: マウス AIM
GenBank ID: 11801
免疫動物: rat(ラット)
精製方法: ProteinG
抗体サブクラス: IgG1,κ
適用 ELISA(1.0μg/mL) Western Blotting(1.0μg/mL) Immuno Precipitation(5μg/mL) Immuno CytoChemistry(1μg/mL)
交差性 マウス
その他 //Function: May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis.
//Subcellular location:Secreted.
//Tissue specificity: Expressed in thymus, liver, spleen and lymph nodes.
//Post-translational modification: Glycosylated.
//Sequence similarities: Contains 3 SRCR domains.
文献
  • Cell Reports, 04 April 2013
    Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells
    Satoko Arai, Natsumi Maehara, Yoshihiro Iwamura, Shin-ichiro Honda, Katsuhiko Nakashima, Toshihiro Kai, Masato Ogishi, Kumiko Morita, Jun Kurokawa, Mayumi Mori, Yuji Motoi, Kensuke Miyake, Nobuyuki Matsuhashi, Ken-ichi Yamamura, Osamu Ohara, Akira Shibuya, Edward K. Wakeland, Quan-Zhen Li, Toru Miyazaki
  • Seikagaku. 2012 Jul;84(7):588-91.
    An optimum method for generation of functional recombinant apoptosis inhibitor of macrophage (AIM) protein
    Ohba M, Nakashima K, Miyazaki T.
  • Cell Metab. 2010 Jun 9;11(6):479-92. doi: 10.1016/j.cmet.2010.04.013.
    Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.
    Kurokawa J, Arai S, Nakashima K, Nagano H, Nishijima A, Miyata K, Ose R, Mori M, Kubota N, Kadowaki T, Oike Y, Koga H, Febbraio M, Iwanaga T, Miyazaki T.
  • Cell Metab. 2005 Mar;1(3):201-13.
    A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.
    Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T.
  • J Exp Med. 1999 January 18; 189(2): 413-422.
    Increased Susceptibility of Thymocytes to Apoptosis in Mice Lacking AIM, a Novel Murine Macrophage-derived Soluble Factor Belonging to the Scavenger Receptor Cysteine-rich Domain Superfamily
    Miyazaki T, Hirokami Y, Matsuhashi N, Takatsuka H, Naito M.
共同研究 東京大学 宮崎 徹先生

2012.06.04発売開始

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