製品名抗 AGEs モノクローナル抗体 (Clone No.6D12) ,Peroxidase conjugated sample


容量 20μg/200μL
価格(税別) お問い合わせください
Data Sheet Data Sheet
免疫抗原: AGEs-BSA
GenBank ID:
免疫動物: mouse(マウス)
精製方法: ProteinG
抗体サブクラス: IgG1
適用 ELISA(0.1-0.5μg/mL) Western Blotting(0.25-5μg/mL) Immuno HistoChemistry(2μg/mL)
交差性 ヒト マウス ラット その他
その他 AGEs(Advanced Glycation End Products)は、タンパク質の非酵素的糖付加反応(メイラード反応)により、シッフ塩基、アマドリ転移生成物(前期生成物)を経由し、脱水、酸化、縮合などの複雑な反応を受けて形成される最終生成物です。AGEs は、蛍光・褐色・分子架橋形成などの特徴の他、AGEs 受容体により認識されるという生化学的特性を有しています。
近年の抗 AGEs 抗体による解析の結果、(1)ヒト水晶体(加齢に伴う増加)、(2)糖尿病性腎症や慢性腎不全患者の腎近位尿細管、(3)糖尿病患者の網膜、(4)糖尿病性神経障害患者の末梢神経、(5)粥状動脈硬化病変部、(6)透析性アミロイド-シスのβ2-マイクログロブリン、(7)アルツハイマー病患者の老人斑、(8)CAPD 患者の腹膜、(9)弾力線維症の皮膚のエラスチン、(10)セロイド/リポフスチン沈着部位などにAGEsが蓄積することが分かってきました。これらの知見は、老化自体や老化に伴う慢性疾患にAGEs が深く関与していることを示唆しています。
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