Antibody Products

Product NameAnti Human Klotho Monoclonal Antibody (Clone No. KM2076)

Cat. No.：
KO603
KO603

Volume： 50μg/200μL
Price： inquiry
Data Sheet Data Sheet
Antigen： human Klotho 55-261a.a.
GenBank ID： 9365
Immunizing animal： rat
Purification： ProteinG
Antibody subclass： IgG2a
Application Western Blotting(1.0-5.0μg/mL) Immuno HistoChemistry(2.0-10μg/mL)
Cross React Human Mouse Rat
Others May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues atpositions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium andphosphorus homeostasis by inhibiting the synthesis of active vitamin D By similarity. Essential factor for the specific interactionbetween FGF23 and FGFR1 By similarity.
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which wouldextend life span by inhibiting insulin/IGF1 signaling By similarity.
Reference
  • Biochem Biophys Res Commun. 2000 Jan 19;267(2):597-602.
    Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys.
    Kato Y, Arakawa E, Kinoshita S, Shirai A, Furuya A, Yamano K, Nakamura K, Iida A, Anazawa H, Koh N, Iwano A, Imura A, Fujimori T, Kuro-o M, Hanai N, Takeshige K, Nabeshima Y.

  • FEBS Lett. 2004 May 7;565(1-3):143-7.
    Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane.
    Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, Fujimori T, Nabeshima Y.

  • Science. 2007 Jun 15;316(5831):1615-8.
    alpha-Klotho as a regulator of calcium homeostasis.
    Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, Obuse C, Togashi K, Tominaga M, Kita N, Tomiyama K, Iijima J, Nabeshima Y, Fujioka M, Asato R, Tanaka S, Kojima K, Ito J, Nozaki K, Hashimoto N, Ito T, Nishio T, Uchiyama T, Fujimori T, Nabeshima Y.
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How to Order

Please contact one of following international distributors.

Cosmo Bio USA, Inc.
E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
Funakoshi Corporation
E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
FUJIFILM Wako Pure Chemical Corporation
E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
Sceti K.K.
E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133