Antibody Products

Product NameAnti MEF Polyclonal Antibody

Cat. No.：
KK053
KK053

Volume： 10μg/100μL
Price： inquiry
Data Sheet Data Sheet
Antigen： His-tagged protein
GenBank ID： 2000
Immunizing animal： rabbit
Purification： Antigen Affinity
Antibody subclass： –
Application Western Blotting(0.2-1.0μg/mL)
Cross React Human
Others The ETS transcription factor family plays a key role in cell growth and differentiation, especially in several malignant and genetic disorders. Recently, it has discovered that MEF（Myeloid ELF-1-like Factor）may compete with ETS-2 for binding to the ets-binding sites on the promoters of the MMP and IL8 which is involved in tumor malignancy.
So that, MEF is expected as a candidate of tumor suppressor. In addition, not like another tumor suppression factor such as p53, MEF is a novel tumor suppressor gene that is located on the X chromosome.
This antibody is very useful for analyzing the MEF expression level in the cell.
Reference
  • Cancer Res. 2002 Nov 15;62(22):6579-86.
    The ETS transcription factor MEF is a candidate tumor suppressor gene on the X chromosome.
    Seki Y, Suico MA, Uto A, Hisatsune A, Shuto T, Isohama Y, Kai H.

  • J Biol Chem. 2004 Apr 30;279(18):19091-8.
    Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.
    Suico MA, Yoshida H, Seki Y, Uchikawa T, Lu Z, Shuto T, Matsuzaki K, Nakao M, Li JD, Kai H.

  • FEBS Lett. 2005 May 23;579(13):2811-6.
    Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells.
    Koga T, Suico MA, Nakamura H, Taura M, Lu Z, Shuto T, Okiyoneda T, Kai H.
Collaborators Dr.Hirofumi Kai at Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.

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How to Order

Please contact one of following international distributors.

Cosmo Bio USA, Inc.
E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
Funakoshi Corporation
E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
FUJIFILM Wako Pure Chemical Corporation
E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
Sceti K.K.
E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133