Antibody Products

Product NameAnti Human phosphorylated TRIO (Trio(Y2681)) Monoclonal Antibody (Clone #29-66)

Cat. No.：
KO626
KO626

Volume： 250μL
Price： inquiry
Data Sheet Data Sheet
Antigen： Partial peptide of Human TRIO including pY2681
GenBank ID： 7204
Immunizing animal： Chicken
Purification： Hydrophobic Interaction Chromatography and Affinity Purified
Antibody subclass： IgY,λ
Application Immuno HistoChemistry(20-50 ng/mL)
Cross React
Others TRIO is the large protein that functions as a RAC/RHO GEF (GTP exchange factor), and promotes reorganization of actin cytoskeleton, thereby playing a key role in cell migration and growth. It is one of the target protein of ABL, and phosphorylation at its Tyr residue 2681 (pY2681) causes RHO activation in colorectal cancer cells. TRIO pY2681 correlates with significantly poorer prognosis with colorectal cancer patients after surgery.
Reference
  • Cancer Discov. 2015 Feb;5(2):198-211
    Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO.
    Sonoshita M, Itatani Y, Kakizaki F, Sakimura K, Terashima T, Katsuyama Y, Sakai Y, Taketo MM.

  • Cancer Cell. 2011 Jan 18;19(1):125-37.
    Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.
    Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A, Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura T, Oshima M, Taketo MM.
Collaborators Kyo Diagnostics Co., LTD.

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How to Order

Please contact one of following international distributors.

Cosmo Bio USA, Inc.
E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
Funakoshi Corporation
E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
FUJIFILM Wako Pure Chemical Corporation
E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
Sceti K.K.
E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133