| Others |
OPRD1 (opioid receptor, delta 1), also known as DOR, belongs to the rhodopsin subfamily of G-protein-coupled receptor (GPCR) family. OPRD1 is consist of 372 amino acids and is located largely in the brain, active T cells. OPRD1 may be responsible for analgesia, dysphoria, immunopotentiation Activation of native T cells markedly up-regulates the expression of OPRD1 and OPRD1 modulates T cell proliferation, IL-2 production, chemotaxis, and intracellular signaling. Stimulating OPRD1 expressed by activated CD4+ T cells significantly suppresses the expression of HIV-1. In addition, it has been showed that activation of OPRD1 is neuroprotective against severe stress, such as hypoxia-, glutamate-induced cell injury. |