Anti Human GPR120 Monoclonal Antibody (Clone No. 2B6)
| Volume： | 25μg/100μL |
| Price： | inquiry |
 Data Sheet |
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| Antigen： | partial peptide |
|---|---|
| GenBank ID： | 338557 |
| Immunizing animal： | GANP® mouse |
| Purification： | ProteinG |
| Antibody subclass： | IgG2aκ |
| Application |  (5μg/mL)  (1.0-5.0μg/mL) |
|---|---|
| Cross React |  |
| Others | GPR120 is a member of G protein-coupled receptor (GPCR) family and functions as a specific receptor for unsaturated long-chain free fatty acids (FFAs) such as palmitoleic acid, -linolenic acid, docosahexaenoic acid. The expression of GPR120 is widely detected in various tissues, and GPR120 is highly expressed in the pituitary, lung, small intestine, colon, and adipose tissues. It has been shown that the stimulation of GPR120 by FFAs promotes the secretion of GLP-1, known as the most potent insulinotropic incretin, from the gastrointestinal tract. It has been also demonstrated that FFAs stimulate the ERK and PI3K-Akt pathways through GPR120 and lead to anti-apoptotic effect in enteroendocrine cell line, and that GPR120 regulates adipogenic process such as adipocyte development and differentiation. In addition, a study suggested that GPR120 is expressed in the taste bud cells in circumvallate papillae to sense dietary fat. This antibody is specific to GPR120 and will be useful for research on diabetes, obesity. |
| Reference | — |
| Collaborators | — |
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How to Order
Please contact one of following international distributors.
- Cosmo Bio USA, Inc.
- E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
- Funakoshi Corporation
- E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
- FUJIFILM Wako Pure Chemical Corporation
- E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
- Sceti K.K.
- E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133