Anti Human TSHR(thyroid stimulating hormone receptor) Monoclonal Antibody (Clone No. 3A6)
| Volume： | 50μg/200μL |
| Price： | inquiry |
 Data Sheet |
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| Antigen： | plasmid vector |
|---|---|
| GenBank ID： | 7253 |
| Immunizing animal： | mouse |
| Purification： | ProteinG |
| Antibody subclass： | IgG2aκ |
| Application |  (1.0-5.0μg/mL) |
|---|---|
| Cross React |  |
| Others | The thyroid stimulating hormone receptor (TSHR) ,also known as LGR3, is a member of the leucine-rich repeat-containing G protein-coupled receptor (LGR) family. TSHR is expressed mainly in thyroid follicular cells and is activated by TSH, which regulates the growth and function of thyroid follicular cells. Graves’ disease is a common type of autoimmune thyroid disease, in that the generation of autoantibodies against the TSHR causes continuous stimulation of the thyroid gland hyperthyroidism. It has been demonstrated that TSHR are present on the surface of melanoma cells, through which TSH promotes melanoma growth. It has been also showed that TSH/TSHR regulates transcription of the TNF gene, osteoclast formation and osteoporosis arise from TSHR deficiency. This antibody is specific to TSHR and will be useful for research on autoimmune thyroid disease, osteoporosis, tumor such as melanoma. |
| Reference | — |
| Collaborators | — |
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How to Order
Please contact one of following international distributors.
- Cosmo Bio USA, Inc.
- E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
- Funakoshi Corporation
- E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
- FUJIFILM Wako Pure Chemical Corporation
- E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
- Sceti K.K.
- E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133