Antibody Products

Product NameAnti Mouse Trpm2 Polyclonal Antibody

Cat. No.：
KO463
sample

Volume： 25μg/100μL
Price： inquiry
Data Sheet Data Sheet
Antigen： partial peptide
GenBank ID： 28240
Immunizing animal： rabbit
Purification： Antigen Affinity
Antibody subclass： –
Application ELISA(1.0μg/mL) Western Blotting(1.0-5.0μg/mL) Immuno CytoChemistry(1.0-5.0μg/mL) Immuno HistoChemistry(5.0-10μg/mL)
Cross React Human Mouse Rat
Others //Function: Nonselective, voltage-independentcation channel mediating sodium and calcium ion influx in response to oxidative stress.
Extracellularcalcium passes through the channel and acts from the intracellularside as a positive regulator in channel activation.Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity.
//Tissue specificity: Widely expressed, with highest levels in lung, spleen, eye and brain.
//Sequence similarities: Belongs to the transient receptor family. LTrpC subfamily. Contains 1 nudix hydrolase domain.
Reference
  • Mol Cell. 2002 Jan;9(1):163-73.
    LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.
    Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y.

  • EMBO J. 2006 May 3;25(9):1804-15.
    TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.
    Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M.

  • Nat Med. 2008 Jul;14(7):738-47.
    TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.
    Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y.
Collaborators Dr. Yasuo Mori, Kyoto University

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