Anti Mouse TRPA1 Polyclonal Antibody
| Volume： | 50μg/200μL |
| Price： | inquiry |
 Data Sheet |
|
| Antigen： | partial peptide |
|---|---|
| GenBank ID： | 277328 |
| Immunizing animal： | rabbit |
| Purification： | Antigen Affinity |
| Antibody subclass： | – |
| Application |  (1.6μg/mL)  (1.6μg/mL) |
|---|---|
| Cross React |  |
| Others | Mammals feel a wide range of temperature spanning from cold to heat with specialized neurons in the peripheral nervous system. With this range, temperatures over about 43 degrees C and below about 15 degrees C evoke not only a thermal sensation, but also a feeling of pain. Nine thermosensitive ion channels have been reported, all of which belong to TRP (transient receptor potential) superfamily. They are expressed in sensory tissues, such as nociceptors and skin. Among them, TRPA1 (TRP cation channel, subfamily A, member 1) has been identified as cold-sensitive ion channel. TRPA1 is activated at approximately 17 degrees C, a temperature that is reported as painfully cold by humans. In addition to noxious cold, TRPA1 is activated pungent ingredients present in mustard, garlic, ginger, clove, wintergreen and cinnamon all and found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (capsaicin/heat receptor). Moreover, TRPA1 has been proposed to be a component of the mechanosensitive transduction channel of vertebrate hair cells. This antibody will be very useful to research the nocifensive (thermosensitive and mechanosensitive) response to pain. |
| Reference |
|
| Collaborators | Dr. Makoto Tominaga Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences |
—
How to Order
Please contact one of following international distributors.
- Cosmo Bio USA, Inc.
- E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
- Funakoshi Corporation
- E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
- FUJIFILM Wako Pure Chemical Corporation
- E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
- Sceti K.K.
- E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133