Antibody Products

Product NameAnti Mouse PDX1 Polyclonal Antibody

Cat. No.：
KR059
KR059

Volume： 25μg/100μL
Price： inquiry
Data Sheet Data Sheet
Antigen： partial peptide
GenBank ID： 18609
Immunizing animal： rabbit
Purification： Antigen Affinity
Antibody subclass： –
Application Immuno HistoChemistry(1.0-5.0μg/mL)
Cross React Mouse
Others Pancreas duodenum homeobox 1 （PDX1） is a transcription factor encoded by homeodomein gene. This protein promotes the transcription of the pancreatic genes such as insulin and somatostatin, so that it is indispensable for keeping normal function of pancreatic beta cell. As it is involved in secretion of insulin, PDX1 becomes therapeutic target against pancreatic diseases such as diabetes and cancer.
This antibody specifically reacts with PDX1 in mouse pancreas and foregut (primordial pancreas). This antibody is useful for immunohistochemistry and could become good research tool for studying pancreatic function, embryology, and diabetes.
Reference
  • J Biol Chem. 2005 Nov 11;280(45):37669-80.
    SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.
    Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, Takayasu S, Kojima N, Iwasaki S, Ohashi R, Jiang S, Hasegawa G, Ioka RX, Magoori K, Sumi K, Maejima T, Uchida A, Naito M, Osborne TF, Yanagisawa M, Yamamoto TT, Kodama T, Sakai J.

  • Glycobiology. 2007 Feb;17(2):127-40.
    Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats.
    Akimoto Y, Hart GW, Wells L, Vosseller K, Yamamoto K, Munetomo E, Ohara-Imaizumi M, Nishiwaki C, Nagamatsu S, Hirano H, Kawakami H.

  • Antioxid Redox Signal. 2008 Jan;10(1):43-9.
    Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus.
    Yamamoto M, Yamato E, Toyoda S, Tashiro F, Ikegami H, Yodoi J, Miyazaki J.
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How to Order

Please contact one of following international distributors.

Cosmo Bio USA, Inc.
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TEL : +1-760-431-4600
FAX : +1-760-431-4600
Funakoshi Corporation
E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
FUJIFILM Wako Pure Chemical Corporation
E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
Sceti K.K.
E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133