Antibody Products

Product NameAnti Human Aurora-A Polyclonal Antibody

Cat. No.：
KR051
KR051

Volume： 25μg/100μL
Price： inquiry
Data Sheet Data Sheet
Antigen： GST fusion protein
GenBank ID： 6790
Immunizing animal： rabbit
Purification： Antigen Affinity
Antibody subclass： –
Application Western Blotting(0.5-2.0μg/mL) Immuno CytoChemistry(1.0-2.0μg/mL)
Cross React Human
Others Aurora-A （ Aurora-A/STK-15/Aik ） encoding a centrosome-associated kinase, is amplified and overexpressed in many cancer cell types, and is involved in the induction of centrosome duplication-distribution abnormalities and aneuploidy in mammalian cells. So that, Aurora-A is a potential oncogene. Aurora family have been identified three types (Aurora-A, B, C） which has high homology domain in C terminal region. Aurora family is indispensable kinase that regulate the structure and function of centrosomes and spindle. Aurora-A could be one of targeting molecule of anti-cancer therapy.
This antibody was established from the purified serum of the immunized rabbit with N terminal region of Aurora-A and did not show any cross- reactivity to Aurora-B and Aurora-C. This antibody is useful for western blotting and immunohistochemistry.
Reference
  • Cancer Res. 2005 Apr 1;65(7):2899-905.
    RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.
    Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A.

  • Clin Cancer Res. 2007 Feb 15;13(4):1331-40.
    The suppression of aurora-A/STK15/BTAK expression enhances chemosensitivity to docetaxel in human esophageal squamous cell carcinoma.
    Tanaka E, Hashimoto Y, Ito T, Kondo K, Higashiyama M, Tsunoda S, Ortiz C, Sakai Y, Inazawa J, Shimada Y.

  • Ann Surg Oncol. 2008 February; 15(2): 547–554.
    Perimembrane Aurora-A Expression is a Significant Prognostic Factor in Correlation with Proliferative Activity in Non-Small-Cell Lung Cancer (NSCLC)
    Ogawa E, Takenaka K, Katakura H, Adachi M, Otake Y, Toda Y, Kotani H, Manabe T, Wada H, Tanaka F.
Collaborators Dr.Saya H. and Dr.Marumoto T. at Department of Tumor Genetics and Biology, Kumamoto University School of medicine.

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How to Order

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Cosmo Bio USA, Inc.
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TEL : +1-760-431-4600
FAX : +1-760-431-4600
Funakoshi Corporation
E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
FUJIFILM Wako Pure Chemical Corporation
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Sceti K.K.
E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133