Anti Nitrotyrosine Monoclonal Antibody ( Clone No.2H1 )
| Volume： | 100μg/400μL |
| Price： | inquiry |
 Data Sheet |
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| Antigen： | Nitrotyrosine-HSA |
|---|---|
| GenBank ID： | – |
| Immunizing animal： | mouse |
| Purification： | ProteinG |
| Antibody subclass： | IgG1 |
| Application | |
|---|---|
| Cross React |  |
| Others | To elucidate the function of Nitric Oxide (NO) related signal transduction, we developed new monoclonal antibody to Nitrotyosin (Clone No.2H1). There are two pathways, which is engaged in the signal transduction regarding vascular relaxation on endothelial cell. One is through activated guanlyate cyclase that is cGMP dependent and another is cGMP independent pathway which requires reactive NO derived substance such as, peroxinitrate(ONOO－), N2O3,N2O4(NO2). Recently, various functions of reactive NO derived substance has been identified for example regulating protein phosphorylation and inducing apoptosis. So, it is believed that reactive NO derived substance is involved in signal transduction among cells. Immunohystochemical study revealed that nitotyrosin residue is produced in some patient such as athrosclerosis, Alzheimer’s disease, Parkinson’s disease, and acute lung damage. This antibody is very useful for the research of reactive NO derived substance. |
| Reference | — |
| Collaborators | — |
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How to Order
Please contact one of following international distributors.
- Cosmo Bio USA, Inc.
- E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
- Funakoshi Corporation
- E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
- FUJIFILM Wako Pure Chemical Corporation
- E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
- Sceti K.K.
- E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133