Anti Human CD147(EMMPRIN) Monoclonal Antibody (Clone No.2G2)
| Volume： | 50μg/200μL |
| Price： | inquiry |
 Data Sheet |
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| Antigen： | human cancer cel line |
|---|---|
| GenBank ID： | 682 |
| Immunizing animal： | mouse |
| Purification： | ProteinG |
| Antibody subclass： | IgG1κ |
| Application |  (5.0-10.0μg/mL)  (0.5-1.0μg/mL) |
|---|---|
| Cross React |  |
| Others | CD147 (also known as Bsg, EMMPRIN) is a 58-kDa transmembrane glycoprotein with two immunoglobulin-like domains and expressed at high levels in many types of tumors and stromal cells. So far, several studies have demonstrated that CD147 plays important role in the progression of malignancies by regulating expression of MMPs (MMP-1, MMP-2, MMP-3, MT-1 MMP) which have important roles in promoting tumor growth, invasion and metastasis. It has been shown that CD147 siRNA inhibited the proliferation, invasiveness, and metastatis activity of human malignant melanoma cell, and that antibody to CD147 inhibit the production of MMPs by fibroblasts and the invasiveness of melanoma cells. In addition to its ability to stimulate stromal MMPs expression, CD147 also induces VEGF and progresses tumor angiogenesis. It has been also shown that CD147 plays a role in systemic lupus erythematosus. This antibody is specific to human CD147 and will be useful for FACS and immunoprecipitation. |
| Reference | — |
| Collaborators | Dr. Kato K. Sapporo medical university |
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How to Order
Please contact one of following international distributors.
- Cosmo Bio USA, Inc.
- E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
- Funakoshi Corporation
- E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
- FUJIFILM Wako Pure Chemical Corporation
- E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
- Sceti K.K.
- E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133