Antibody Products

Product NameAnti Human Macrophage Scavenger Receptor A (MSR- A:CD204) Monoclonal Antibody (Clone No. SRA-C6)

Cat. No.：
KT118
KT118

Volume： 50μg/200μL
Price： inquiry
Data Sheet Data Sheet
Antigen： recombinant protein
GenBank ID： 4481
Immunizing animal： mouse
Purification： ProteinG
Antibody subclass： IgG1
Application Western Blotting(1μg/mL) Immuno HistoChemistry(5μg/mL)
Cross React Human
Others Class A macrophage scavenger receptor (MSR-A: CD204) was identified in the search for the receptor molecules that are implicated in the pathological deposition of cholesterol during atherogenesis through receptor-mediated uptake of modified low density lipoprotein (LDL). MSR-A possesses a wide range of ligand-binding specificities and recognize a variety of molecules such as modified LDL including acetylated LDL, oxidized LDL, advanced glycation end products (AGEs), polyribonucleotides such as poly G and poly I and bacterial surface lipids including lipopolysaccharide and lipoteicoic acid.
This antidody was produced from the mouse immunized with recombinant protein of human type I MSR-A ,and has been proved to be useful for the western blotting and immunohistochemistry. This antibody also inhibits the endocytic degradation of acetylated LDL and oxidized LDL by high glucose-treated human monocyte-derived macrophages and has anti MSR-A neutralizing activity.
This antibody is useful tools for the study of MSR-A in atherogenesis and various other pathological conditions.
Reference
  • Atherosclerosis. 2002 Mar;161(1):123-32.
    Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors.
    Tomokiyo R, Jinnouchi K, Honda M, Wada Y, Hanada N, Hiraoka T, Suzuki H, Kodama T, Takahashi K, Takeya M.

  • J Biol Chem. 2005 Feb 4;280(5):3355-64.
    Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes.
    Fukuhara-Takaki K, Sakai M, Sakamoto Y, Takeya M, Horiuchi S.

  • Cancer Res. 2007 May 15;67(10):4783-9.
    Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression.
    Bak SP, Walters JJ, Takeya M, Conejo-Garcia JR, Berwin BL.
Collaborators Dr. Takeya M., Second Department of Pathology, Kumamoto University School of Medicine, Kumamoto, Japan

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How to Order

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Cosmo Bio USA, Inc.
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Funakoshi Corporation
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FUJIFILM Wako Pure Chemical Corporation
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Sceti K.K.
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