Antibody Products

Product NameAnti Human Macrophage Scavenger Receptor A (MSR-A:CD204) Monoclonal Antibody ( Clone No.SRA-E5 )

Cat. No.：
KT022
KT022

Volume： 50μg/200μL
Price： inquiry
Data Sheet Data Sheet
Antigen： recombinant protein
GenBank ID： 4481
Immunizing animal： mouse
Purification： ProteinG
Antibody subclass： IgG1
Application Western Blotting(2μg/mL) Immuno HistoChemistry(10μg/mL)
Cross React Human
Others Macrophage scavenger receptor (MSR-A: CD204) was identified in the search for the receptor molecules that are implicated in the pathological deposition of cholesterol during atherogenesis through receptor-mediated uptake of modified low density lipoproteins (LDL).
MSR-As possess a wide range of ligand-binding specificities and recognize a variety of molecules such as modified LDL including acetylated LDL, oxidized LDL, advanced glycation end products (AGE), polyribonucleotides such as poly G and poly I and bacterial surface lipids including lipopolysaccharide and lipoteicoic acid.
This antidody was produced from the mouse immunized with recombinant protein of human type I MSR-A ,and has been proved to be useful for the immunoblotting and immunohistochemistry.
This antibody is useful tools for the study of MSR in atherogenesis and various other pathological conditions in humans and animal species.
Reference
  • Atherosclerosis. 2002 Mar;161(1):123-32.
    Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors.
    Tomokiyo R, Jinnouchi K, Honda M, Wada Y, Hanada N, Hiraoka T, Suzuki H, Kodama T, Takahashi K, Takeya M.

  • J Biol Chem. 2005 Feb 4;280(5):3355-64.
    Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes.
    Fukuhara-Takaki K, Sakai M, Sakamoto Y, Takeya M, Horiuchi S.

  • J Pathol. 2007 May;212(1):38-46.
    Class A scavenger receptor (CD204) attenuates hyperoxia‐induced lung injury by reducing oxidative stress
    Kobayashi H, Sakashita N, Okuma T, Terasaki Y, Tsujita K, Suzuki H, Kodama T, Nomori H, Kawasuji M, Takeya M.

  • J Pathol. 2008 May;215(1):48-55.
    Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions.
    Savchenko A, Imamura M, Ohashi R, Jiang S, Kawasaki T, Hasegawa G, Emura I, Iwanari H, Sagara M, Tanaka T, Hamakubo T, Kodama T, Naito M.

  • J Immunol. 2008 Nov 1;181(9):6503-13.
    IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.
    Shimizu E, Kawahara K, Kajizono M, Sawada M, Nakayama H.

  • Vet Pathol. 2009 May;46(3):520-5.
    Vasoformative Disorder, Resembling Littoral Cell Angioma, of the Spleen in a Geriatric Japanese Macaque (Macaca fuscata)
    Yamate J, Izawa T, Kuwamura M, Mitsunaga F, Nakamura S.

  • Exp Dermatol. 2009 Aug;18(8):727-9.
    Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma.
    Higashi-Kuwata N, Makino T, Inoue Y, Takeya M, Ihn H.

  • Pathol Int. 2009 May;59(5):300-5.
    Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors
    Kawamura K, Komohara Y, Takaishi K, Katabuchi H, Takeya M.

  • J Surg Res. 2009 Jun 16
    Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer.
    Kurahara H, Shinchi H, Mataki Y, Maemura K, Noma H, Kubo F, Sakoda M, Ueno S, Natsugoe S, Takao S.

  • Pathol Int. 2010 Jan;60(1):27-34.
    Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype: their possible involvement in pathological processes.
    Ohnishi K, Komohara Y, Sakashita N, Iyama K, Murayama T, Takeya M.

  • Arthritis Res Ther. 2010;12(4):R128.
    Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis.
    Higashi-Kuwata N, Jinnin M, Makino T, Fukushima S, Inoue Y, Muchemwa FC, Yonemura Y, Komohara Y, Takeya M, Mitsuya H, Ihn H.

  • Exp Toxicol Pathol. 2010 Jul 7.
    Immunohistochemical analyses of the kinetics and distribution of macrophages, hepatic stellate cells and bile duct epithelia in the developing rat liver.
    Golbar HM, Izawa T, Murai F, Kuwamura M, Yamate J.

  • Neuropathology. 2010 Dec 1. doi: 10.1111/j.1440-1789
    Immunohistochemical characterization of microglia in Nasu‐Hakola disease brains
    Satoh JI, Tabunoki H, Ishida T, Yagishita S, Jinnai K, Futamura N, Kobayashi M, Toyoshima I, Yoshioka T, Enomoto K, Arai N, Arima K.

  • Atherosclerosis. 2011 Mar;215(1):60-9.
    Involvement of cholesterol-enriched microdomains in class A scavenger receptor-mediated responses in human macrophages.
    Kiyanagi T, Iwabuchi K, Shimada K, Hirose K, Miyazaki T, Sumiyoshi K, Iwahara C, Nakayama H, Masuda H, Mokuno H, Sato S, Daida H.
Collaborators Dr. Takeya M., Second Department of Pathology, Kumamoto University School of Medicine, Kumamoto, Japan

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