Anti Mouse Semaphorin 4A Monoclonal Antibody (Clone No. HIAT-2)
| Volume： | 25μg/100μL |
| Price： | inquiry |
 Data Sheet |
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| Antigen： | recombinant protein |
|---|---|
| GenBank ID： | 20351 |
| Immunizing animal： | Sema4A K.O. mouse |
| Purification： | ProteinG |
| Antibody subclass： | IgG1κ |
| Application |  (1.0-10μg/mL)  (5.0μg/mL)  (0.05μg/mL) |
|---|---|
| Cross React |   |
| Others | Semaphorins are a family of phylogenetically conserved soluble and transmembrane proteins. Semaphorins were originally identified as axon guidance factors during neuronal development. Semaphorins are now known to be widely expressed mediators that play significant roles in immune responses and organ morphogenesis. The class IV semaphoring subfamily member, Sema4A was identified originally as a semaphorin expressed in developing embryos, and Sema4A transcript levels increase gradually throughout embryonic development. Sema4A is expressed in the brain, lung, kidney, testis, and spleen of adults. In the immune system, Sema4A is preferentially expressed by bone marrow-derived and splenic dendritic cells (DCs), but not by resting T cells. Expression of Sema4A also becomes detectable on the cell surface of T cells following activation. Sema4A regulates T-cell-mediated immune responses by interacting with its receptor Tim-2, which is expressed on TH2 cells as a negative regulator. Sema4A expression is specifically induced on the cell surface of TH1 cells during helper T-cell differentiation. T-cell derived Sema4A is necessary for regulating T-cell differentiation. Sema4A expressed on endothelial cells, directly binds to Plexin-D1 and negatively regulates VEGF-dependent vascular formation. It is also suggested that Sema4A is critically involved in the development of myocarditis and dilated cardiomyopathy. |
| Reference | — |
| Collaborators | — |
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How to Order
Please contact one of following international distributors.
- Cosmo Bio USA, Inc.
- E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
- Funakoshi Corporation
- E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
- FUJIFILM Wako Pure Chemical Corporation
- E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
- Sceti K.K.
- E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133