Antibody Products

Product NameAnti Rat Autotaxin /ENPP2 Polyclonal Antibody

Cat. No.:
KM106
sample

Volume: 25μg/250μL
Price: inquiry
Data Sheet Data Sheet
Antigen: partial peptide
GenBank ID: 18606
Immunizing animal: rabbit
Purification: Antigen Affinity
Antibody subclass:
Application Western Blotting(0.5μg/mL)
Cross React Rat
Others Autotaxin, a member of the ENPP (Ectonucleotide pyrophospatase/phosphodiesterase) family of ectoenzymes, was originally identified as a motogen secreted by a melanoma cell line and subsequently reported to promote cell proliferation, cell motility, angiogenesis, and neurite retraction. Autotaxin has lysophospholipase D activity and appears to exert its effects by generation of the lipid mediator lysophosphatidic acid (LPA) from lysophosphatidylcholine and sphingosine 1-phosphate (S1P) from sphingosylphosphorylcholine (SPC) outside the cell.
Autotaxin levels are significantly higher in cancerous tissues than in normal tissues suggesting that this novel extracellular protein may be involved in tumor progression.

Two Autotaxin antibodies are available;
KM105: Specifically reacts with a C-terminal fragment of Autotaxin
KM106: Specifically reacts with an N-terminal fragment of Autotaxin

Reference
  • J Biol Chem. 2009 Nov 27;284(48):33561-70.
    Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac.
    Koike S, Keino-Masu K, Ohto T, Sugiyama F, Takahashi S, Masu M.
Collaborators Dr. Masu M. and Dr.Koike S. Graduate School of Comprehensive Human Sciences, University of Tsukuba

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How to Order

Please contact one of following international distributors.

Cosmo Bio USA, Inc.
E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
Funakoshi Corporation
E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
FUJIFILM Wako Pure Chemical Corporation
E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
Sceti K.K.
E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133