Antibody Products

Product NameAnti Human L-type Amino Acid Transporter 1(LAT1) Polyclonal Antibody

Cat. No.：
KE026
sample

Volume： 25μg/250μL
Price： inquiry
Data Sheet Data Sheet
Antigen： partial peptide
GenBank ID： 8140
Immunizing animal： rabbit
Purification： Antigen Affinity
Antibody subclass： –
Application Immuno HistoChemistry(5.0-10.0μg/mL)
Cross React Human
Others Mammalian amino acid transport system is consisted of large variety of transporters, with the reflection of amino acid molecule variety, and is clessfied into various transport systems by the transportative substrate selectivity and the Na+ dependence with the reflection of amino acid molecule variety.
L-type amino acid transporter 1 (LAT1) is a predicted 12 membrane-spanning protein and is unique because it requires an additional single membrane spanning protein, 4F2 heavy chain (4F2hc:CD98), for its functional expression. L-type is Na+ -independent neutral amino acid transporter agency and essential for the transporter of large neutral amino acid such as Leucine, Isoleucine, Varine through the plasma membrane. LAT1 is, thus transporter responsible for the permeation of aromatic or branched-chain amino acids and amino acid-related drugs such as L-DOPA. LAT has been proposed to be one of the major nutrient transport systems at the blood-brain barrier. Highly regulated nature and high level of expression in tumor cell lines, LAT is thought to be up-regulated to support the high protein synthesis for cell glowth and cell activation.
This antibody has been proved to be useful for the immunohistochemistry.
Reference
  • Biochim Biophys Acta. 2002 Sep 20;1565(1):112-21.
    Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells.
    Kim DK, Kanai Y, Choi HW, Tangtrongsup S, Chairoungdua A, Babu E, Tachampa K, Anzai N, Iribe Y, Endou H.

  • Cancer Lett. 2004 Mar 18;205(2):215-26.
    Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells.
    Yoon JH, Kim YB, Kim MS, Park JC, Kook JK, Jung HM, Kim SG, Yoo H, Ko YM, Lee SH, Kim BY, Chun HS, Kanai Y, Endou H, Kim DK.

  • Anticancer Res. 2004 May-Jun;24(3a):1671-5.
    Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in oral squamous cell carcinoma and its precusor lesions.
    Kim DK, Ahn SG, Park JC, Kanai Y, Endou H, Yoon JH.

  • Cancer Lett. 2005 May 26;222(2):237-45.
    Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells.
    Yoon JH, Kim IJ, Kim H, Kim HJ, Jeong MJ, Ahn SG, Kim SA, Lee CH, Choi BK, Kim JK, Jung KY, Lee S, Kanai Y, Endou H, Kim DK.

  • In Vivo. 2006 Sep-Oct;20(5):591-7.
    Expression of amino acid transporter LAT1 and 4F2hc in the healing process after the implantation of a tooth ash and plaster of Paris mixture.
    Kim SG, Ahn YC, Yoon JH, Kim HK, Park SS, Ahn SG, Endou H, Kanai Y, Park JC, Kim do K.

  • Anticancer Res. 2008 Sep-Oct;28(5A):2649-55.
    Characterization of amino acid transport system L in HTB-41 human salivary gland epidermoid carcinoma cells.
    Park NS, Kim SG, Kim HK, Moon SY, Kim CS, Cho SH, Kanai Y, Endou H, Kim do K.

  • Acta Neurochir Suppl. 2008;102:385-8.
    Up-regulation of L type amino acid transporter 1 after spinal cord injury in rats.
    Toyooka T, Nawashiro H, Shinomiya N, Yano A, Ooigawa H, Ohsumi A, Uozumi Y, Yanagawa Y, Matsuo H, Shima K.

  • Biol. Pharm. Bull. 2008 Vol. 31, 395-399
    Differential Expression of System L Amino Acid Transporters during Wound Healing Process in the Skin of Young and Old Rats
    Moon-Jin Jeong, Chun Sung Kim, Joo-Cheol Park, Heung-Joong Kim, Yeong Mu Ko, Kyung Jin Park, Soon-Jeong Jeong, Hitoshi Endou, Yoshikatsu Kanai, Do-Seon Lim and Do Kyung Kim

  • Int J Gynecol Cancer. 2010 Apr;20(3):329-36.
    Properties of L-type amino acid transporter 1 in epidermal ovarian cancer.
    Kaji M, Kabir-Salmani M, Anzai N, Jin CJ, Akimoto Y, Horita A, Sakamoto A, Kanai Y, Sakurai H, Iwashita M.
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