Antibody Products

Product NameAnti Human L-type Amino Acid Transporter 1 (LAT1) Monoclonal Antibody ( Clone No. 4D9 )

Cat. No.：
KE023
KE023

Volume： 20μg/100μL
Price： inquiry
Data Sheet Data Sheet
Antigen： partial peptide
GenBank ID： 8140
Immunizing animal： mouse
Purification： ProteinG
Antibody subclass： IgM
Application Immuno HistoChemistry(2.0-5.0μg/mL)
Cross React Human
Others Mammalian amino acid transport system is consisted of large variety of transporters, with the reflection of amino acid molecule variety, and is clessfied into various transport systems by the transportative substrate selectivity and the Na+ dependence with the reflection of amino acid molecule variety.
L-type amino acid transporter 1 (LAT1) is a predicted 12 membrane-spanning protein and is unique because it requires an additional single membrane spanning protein, 4F2 heavy chain (4F2hc:CD98), for its functional expression. L-type is Na+ -independent neutral amino acid transporter agency and essential for the transporter of large neutral amino acid such as Leucine, Isoleucine, Varine through the plasma membrane. LAT1 is, thus transporter responsible for the permeation of aromatic or branched-chain amino acids and amino acid-related drugs such as L-DOPA. LAT has been proposed to be one of the major nutrient transport systems at the blood-brain barrier. Highly regulated nature and high level of expression in tumor cell lines, LAT is thought to be up-regulated to support the high protein synthesis for cell glowth and cell activation.
This antibody has been proved to be useful for the immunohistochemistry.
Reference
  • Virchows Arch. 2006 Feb;448(2):142-50.
    LAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
    Nakanishi K, Matsuo H, Kanai Y, Endou H, Hiroi S, Tominaga S, Mukai M, Ikeda E, Ozeki Y, Aida S, Kawai T.

  • Int J Gynecol Cancer. 2010 Apr;20(3):329-36.
    Properties of L-type amino acid transporter 1 in epidermal ovarian cancer.
    Kaji M, Kabir-Salmani M, Anzai N, Jin CJ, Akimoto Y, Horita A, Sakamoto A, Kanai Y, Sakurai H, Iwashita M.
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How to Order

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Cosmo Bio USA, Inc.
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Funakoshi Corporation
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FUJIFILM Wako Pure Chemical Corporation
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Sceti K.K.
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