Antibody Products

Product NameAnti Human 4F2 Heavy Chain (4F2hc:CD98) Polyclonal Antibody

Cat. No.：
KE020
sample

Volume： 250μg/500μL
Price： inquiry
Data Sheet Data Sheet
Antigen： partial peptide
GenBank ID： 6520
Immunizing animal： rabbit
Purification： ProteinG
Antibody subclass： –
Application Immuno HistoChemistry(50μg/mL)
Cross React Human
Others Mammalian amino acid transport system is consisted of large variety of transporters with the reflection of amino acid molecule variety, and is classfied into various transport systems by the transportative substrate selectivity and the Na+ dependence with the reflection of amino acid molecule variety.
4F2 heavy chain（4F2hc:CD98）is originally identified as a cell-surface antigen which is upregulated by　lymphocyte activation, and is a single memblane-spanning protein, of which molecular weight is under 85-kDa. The transporter corresponds to the amino acid transporter, system L, y+L, X-c, and asc, which requires 4F2hc for its functional expression. 4F2hc and its associated transporters are linked via disulfide band to form heterodimeric complexes. 4F2hc is present at cell membrane in blood vessel side of epitherliocyte, and transports its associated transporters to cell membrane of blood vessel in epitherliocyte.
This antidody has been proved to be useful for immunohistochemistry.
Reference
  • Cancer Lett. 2004 Mar 18;205(2):215-26.
    Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells.
    Yoon JH, Kim YB, Kim MS, Park JC, Kook JK, Jung HM, Kim SG, Yoo H, Ko YM, Lee SH, Kim BY, Chun HS, Kanai Y, Endou H, Kim DK.

  • Anticancer Res. 2004 May-Jun;24(3a):1671-5.
    Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in oral squamous cell carcinoma and its precusor lesions.
    Kim DK, Ahn SG, Park JC, Kanai Y, Endou H, Yoon JH.

  • Anticancer Res. 2006 May-Jun;26(3A):1989-96.
    Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells.
    Kim SG, Kim HH, Kim HK, Kim CH, Chun HS, Kanai Y, Endou H, Kim do K.

  • In Vivo. 2006 Sep-Oct;20(5):591-7.
    Expression of amino acid transporter LAT1 and 4F2hc in the healing process after the implantation of a tooth ash and plaster of Paris mixture.
    Kim SG, Ahn YC, Yoon JH, Kim HK, Park SS, Ahn SG, Endou H, Kanai Y, Park JC, Kim do K.

  • Anticancer Res. 2008 Sep-Oct;28(5A):2649-55.
    Characterization of amino acid transport system L in HTB-41 human salivary gland epidermoid carcinoma cells.
    Park NS, Kim SG, Kim HK, Moon SY, Kim CS, Cho SH, Kanai Y, Endou H, Kim do K.
Collaborators —

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How to Order

Please contact one of following international distributors.

Cosmo Bio USA, Inc.
E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
Funakoshi Corporation
E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
FUJIFILM Wako Pure Chemical Corporation
E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
Sceti K.K.
E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133