Anti AGE-4 Monoclonal Antibody ( Clone No. 14B5 )
| Volume： | 10μg/40μL |
| Price： | inquiry |
 Data Sheet |
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| Antigen： | AGE4-BSA |
|---|---|
| GenBank ID： | – |
| Immunizing animal： | GANP® mouse |
| Purification： | ProteinG |
| Antibody subclass： | IgG1κ |
| Application |  (0.05μg/mL)  (0.1μg/mL) |
|---|---|
| Cross React |     |
| Others | The products of the nonenzymatic glycation and oxidation of proteins, lipids and nucleic acids, the advanced glycation end-products (AGEs), accumulate in various pathological conditions, such as diabetes, inflammation, renal failure, and aging. AGEs accumulate at site of microvascular injury in diabetes, including the kidney, the retina, and within the vasculature. The enhanced formation of AGEs also exists in various disease, such as atherosclerosis, Alzheimer’s disease, end-stage renal disease (ESRD), rheumatoid arthritis and liver cirrhosis. AGEs can arise not only from glucose, but also from dicarbonyl compounds, short chain-reducing sugars and other metabolic pathways of glucose. Methylglyoxal (MG) increases in diabetes and can modify proteins rapidly and form AGE-4. It has been showed that exogenously added MG has a strong synergistic effect on TNF-induced cell death and AGE-4 is formed during TNF-induced cell in death mouse L929 cell, and that increased MG and AGE-4 levels induce apoptosis in mycobacterial-infected macrophages. It also has been demonstrated that MG rapidly modifies the PTP covalently and stabilizes the PTP in the closed conformation in rat liver mitochondria. Moreover, it has been showed that an increase in intracellular MG concentration inhibit the insulin signaling pathway and leads to an insulin-resistant state in L6 muscle cells. This antibody is specific to AGE-4 and will be useful to research for diabetes, chromic diseases associated with aging and diabetic complications, cell death. |
| Reference | — |
| Collaborators | — |
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How to Order
Please contact one of following international distributors.
- Cosmo Bio USA, Inc.
- E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
- Funakoshi Corporation
- E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
- FUJIFILM Wako Pure Chemical Corporation
- E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
- Sceti K.K.
- E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133