Anti Human AdipoR1 Polyclonal Antibody
| Volume： | 100μg/400μL |
| Price： | inquiry |
 Data Sheet |
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| Antigen： | partial peptide |
|---|---|
| GenBank ID： | 51094 |
| Immunizing animal： | rabbit |
| Purification： | Antigen Affinity |
| Antibody subclass： | – |
| Application |  (1μg/mL) |
|---|---|
| Cross React |   |
| Others | Obesity is a common etiology of diabetes mellitus and other diseases. Certain adipocytokines are considered beneficial due to their ability to enhance insulin sensitivity, while others, considered detrimental, enhance insulin resistance. The beneficial adipocytokine adiponectin displays both anti-diabetic and anti-arteriosclerotic effects. Two distinct adiponectin receptors have been identified. Both AdipoR1 and AdipoR2 are seven-pass transmembrane receptors but are structurally, topologically, and functionally distinct from G-protein coupled receptors (GPCR). AdipoR1 is most abundant in muscle whereas AdipoR2 is most abundant in liver. Both receptors promote fatty acid oxidation and glucose uptake by AMP-activated protein kinase and PPARα. PPAR agonists are reported to increase expression of activated adiponectin. PPARα agonists also increase expression of adiponectin receptors. Such findings have focused attention on the role of AdipoR1 in PPAR agonist development. |
| Reference | — |
| Collaborators | — |
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How to Order
Please contact one of following international distributors.
- Cosmo Bio USA, Inc.
- E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
- Funakoshi Corporation
- E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
- FUJIFILM Wako Pure Chemical Corporation
- E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
- Sceti K.K.
- E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133