Anti Human RAGE Polyclonal Antibody
| Volume： | 100μg/400μL |
| Price： | inquiry |
 Data Sheet |
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| Antigen： | partial peptide |
|---|---|
| GenBank ID： | 177 |
| Immunizing animal： | rabbit |
| Purification： | ProteinG |
| Antibody subclass： | – |
| Application |  (2μg/mL) |
|---|---|
| Cross React |  |
| Others | RAGE is the receptor of AGEs, advanced glycation end products with 35,000 molecular weight and was cloned from bovine lung in 1992 ( David Stern et al.,). RAGE has been found in several tissues such as monocytes, macrophages, endothelial cells, astocytes. The ligand of RAGE is demonstrated not only AGEs but also anfoterin, EN-RAGE, N-carboxymethyllysine(CML),β-amyloid and so on. The accumulation of AGEs-proteins in vivo has been demonstrated in several disease, it is not clear whether AGEs-proteins accumulated in vivo is a direct cause of the disease or rather reflects its effect. Regarding this issue, AGEs-modified proteins are known to interact with several cells by the AGEs-receptors and induce several cellular phenomena. Recently, it has been discovered that RAGE is involved in pathophysiological function of diabetes and Alzheimer’s disease. This antibody is affinity purified rabbit polyclonal antibody raised against partial peptide of human RAGE and should be used for western blotting or immunohistochmistry. |
| Reference |
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| Collaborators | Prof. Horiuchi S. Department of Biochemistry Kumamoto University School of Medicine |
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How to Order
Please contact one of following international distributors.
- Cosmo Bio USA, Inc.
- E-mail : info@cosmobiousa.com
TEL : +1-760-431-4600
FAX : +1-760-431-4600
- Funakoshi Corporation
- E-mail : reagent@funakoshi.co.jp
TEL : +81-3-5684-1620
FAX : +81-3-5684-1775
- FUJIFILM Wako Pure Chemical Corporation
- E-mail : ffwk-labchem-tec@fujifilm.com
TEL : 0120-052-099 (only in Japan)
FAX : 0120-052-806 (only in Japan)
- Sceti K.K.
- E-mail : export@sceti.co.jp
TEL : +81-3-5510-2652
FAX : +81-3-5510-0133